The MikesPickz NFL Picks are back again for the 2025-26 season.
As usual, I will make my picks for each game, every week of the NFL season using the point spread from the ESPN Pigskin Pick’em Challenge. After each week, the post will be updated with the results. My full pick record for all seasons (19 and counting) can be found on the historical picks page.
The favorite will be marked with the spread in parenthesis next to the team name. For example, Patriots (-6.5). My best bet is the team that I feel is most likely to win and cover the spread this week.
Welcome to Week 2 of the NFL Season! Without further adieu, here are my picks:
Week 2 BYE WEEKS: None
Best Bet: 49ers (-4.5) – Win
Week 1 Recap: 6-4-0, 1-0 Best Bet, 1-0 Survivor pool
Thursday Night Football:
- Commanders at Packers (-3.5)
- The pick: Packers (-3.5) – WIN
Sunday Early Games:
- Jaguars at Bengals (-3.5)
- The pick: Bengals (-3.5) – WIN
- Giants at Cowboys (-5.5)
- The pick: Cowboys (-5.5) – LOSS
- Bears at Lions (-5.5)
- The pick: Lions (-5.5) – WIN
- Rams (-5.5) at Titans
- The pick: Titans (+5.5) – LOSS
- Patriots at Dolphins (-1.5)
- The pick: Patriots (+1.5) – WIN
- 49ers (-4.5) at Saints
- The pick: 49ers (-4.5) – BEST BET – WIN
- Bills (-6.5) at Jets
- The pick: Jets (+6.5) – LOSS
- Seahawks at Steelers (-2.5)
- The pick: Seahawks (+2.5) – WIN
- Browns at Ravens (-12.5)
- The pick: Browns (+12.5) – LOSS
Sunday Late Games:
- Broncos (-2.5) at Colts
- The pick: Broncos (-2.5)
- Panthers at Cardinals (-6.5)
- The pick: Cardinals (-6.5)
- Eagles (-1.5) at Chiefs
- The pick: Chiefs (+1.5)
Sunday Night Football:
- Falcons at Vikings (-4.5)
- The pick: Falcons (+4.5)
- The pick: Falcons (+4.5)
Monday Night Football:
- Bucs at Texans (-2.5)
- The pick: Bucs (+2.5)
- Chargers (-3.5) at Raiders
- The pick: Chargers (-3.5)
Regular Season Record: 8-8-0 (50.00%)
Postseason Record: N/A
Best Bet Record: 0-1
Last Season’s Record: 139-133-0 (51.10%)
Click here for my Full Historical Pick Records
King of the Hill aka Lock of the Week aka Survivor Pool Picks:
In this section, I will post my pick for a survivor pool. Once a team is used, I can’t use them again for the rest of the season. The team selected only has to win the game, not cover the spread. Pick One and Pick Two are independent of each other. If I use a team with Pick One, I can use them later with Pick Two.
| Week | Pick One | Pick Two |
| Week 1 | Cardinals – Win | Broncos – Win |
| Week 2 | Cowboys – Win | Cardinals |
| Week 3 | ||
| Week 4 | ||
| Week 5 | ||
| Week 6 | ||
| Week 7 | ||
| Week 8 | ||
| Week 9 | ||
| Week 10 | ||
| Week 11 | ||
| Week 12 | ||
| Week 13 | ||
| Week 14 | ||
| Week 15 | ||
| Week 16 | ||
| Week 17 | ||
| Week 18 | ||
| Total | 2-0 | 1-0 |
