2025-26 NFL Picks Against the Spread: Week 10

The MikesPickz NFL Picks are back again for the 2025-26 season.

As usual, I will make my picks for each game, every week of the NFL season using the point spread from the ESPN Pigskin Pick’em Challenge. After each week, the post will be updated with the results. My full pick record for all seasons (19 and counting) can be found on the historical picks page.

The favorite will be marked with the spread in parenthesis next to the team name. For example, Patriots (-6.5). My best bet is the team that I feel is most likely to win and cover the spread this week.

Welcome to Week 10 of the NFL Season! Without further adieu, here are my picks:

Week 10 BYE WEEKS: Bengals, Cowboys, Chiefs, Titans
Best Bet: Jets (-2.5) – Win
Week 10 Recap: 7-7, 1-0 Best Bet, 0-2 Survivor pool

Thursday Night Football:

  • Raiders at Broncos (-9.5)
    • The pick: Broncos (-9.5) – LOSS

Sunday Early Games:

  • Falcons at Colts (-5.5) (9:30AM EST – IN BERLIN)
    • The pick: Colts (-5.5) – WIN
  • Giants at Bears (-3.5)
    • The pick: Giants (+3.5) – LOSS
  • Bills (-8.5) at Dolphins
    • The pick: Bills (-8.5) – LOSS
  • Ravens (-4.5) at Vikings
    • The pick: Vikings (+4.5) – LOSS
  • Browns at Jets (-2.5)
    • The pick: Jets (-2.5) – BEST BET – WIN
  • Patriots at Bucs (-2.5)
    • The pick: Patriots (+2.5) – WIN
  • Saints at Panthers (-5.5)
    • The pick: Saints (+5.5) – WIN
  • Jaguars at Texans (-1.5)
    • The pick: Texans (-1.5) – WIN

Sunday Late Games:

  • Cardinals at Seahawks (-6.5)
    • The pick: Seahawks (-6.5) – WIN
  • Rams (-3.5) at 49ers
    • The pick: 49ers (+3.5) – LOSS
  • Lions (-8.5) at Commanders
    • The pick: Lions (-8.5) – WIN

Sunday Night Football:

  • Steelers at Chargers (-3.5)
    • The pick: Steelers (+3.5) – LOSS

Monday Night Football:

  • Eagles at Packers (-2.5)
    • The pick:Packers (-2.5) – LOSS

Previous Week’s Record: 7-7

Regular Season Record: 62-73-0 (45.93%)

Postseason Record: N/A

Best Bet Record: 5-4

Last Season’s Record: 139-133-0 (51.10%)

Click here for my Full Historical Pick Records


King of the Hill aka Lock of the Week aka Survivor Pool Picks:
In this section, I will post my pick for a survivor pool. Once a team is used, I can’t use them again for the rest of the season. The team selected only has to win the game, not cover the spread. Pick One and Pick Two are independent of each other. If I use a team with Pick One, I can use them later with Pick Two.

Week Pick One Pick Two
Week 1 Cardinals – Win Broncos – Win
Week 2 Cowboys – Win Cardinals – Win
Week 3 Seahawks – Win Bucs – Win
Week 4 Broncos – Win Texans – Win
Week 5 Lions – Win Colts – Win
Week 6 Packers – Win Rams – Win
Week 7 Patriots – Win Bears – Win
Week 8 Colts – Win Falcons – Loss
Week 9 Rams – Win Packers – Loss
Week 10 Bills – Loss Panthers – Loss
Week 11
Week 12
Week 13
Week 14
Week 15
Week 16
Week 17
Week 18
Total 9-1 7-3
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