2025-26 NFL Picks Against the Spread: Week 17

The MikesPickz NFL Picks are back again for the 2025-26 season.

As usual, I will make my picks for each game, every week of the NFL season using the point spread from the ESPN Pigskin Pick’em Challenge. After each week, the post will be updated with the results. My full pick record for all seasons (19 and counting) can be found on the historical picks page.

The favorite will be marked with the spread in parenthesis next to the team name. For example, Patriots (-6.5). My best bet is the team that I feel is most likely to win and cover the spread this week.

Welcome to Week 17 of the NFL Season! Without further adieu, here are my picks:

Week 17 BYE WEEKS: N/A
Best Bet: 49ers (-2.5) – WIN
Week 17 Recap: 9-7, 1-0 Best Bet, 2-0 Survivor pool

Christmas Football:

  • Cowboys (-6.5) at Commanders
    • The pick: Cowboys (-6.5) – WIN
  • Lions (-5.5) at Vikings
    • The pick: Lions (-5.5) – LOSS
  • Broncos (-12.5) at Chiefs
    • The pick: Broncos (-12.5) – LOSS

Saturday Football:

  • Texans at Chargers (-2.5)
    • The pick:Texans (+2.5) – WIN
  • Ravens at Packers (-2.5)
    • The pick: Ravens (+2.5) – WIN

Sunday Early Games:

  • Seahawks (-7.5) at Panthers
    • The pick:Panthers (+7.5) – LOSS
  • Bucs (-5.5) at Dolphins
    • The pick: Bucs (-1.5) – LOSS
  • Cardinals at Bengals (-7.5)
    • The pick: Bengals (-7.5) – WIN
  • Saints (-2.5) at Titans
    • The pick: Saints (-2.5) – WIN
  • Patriots (-13.5) at Jets
    • The pick: Patriots (-13.5) – WIN
  • Steelers (-3.5) at Browns
    • The pick: Steelers (-3.5) – LOSS
  • Jaguars (-6.5) at Colts
    • The pick:Colts (+6.5) – WIN

Sunday Late Games:

  • Giants at Raiders (-1.5)
    • The pick: Giants (+1.5) – WIN
  • Eagles at Bills (-1.5)
    • The pick: Bills (-1.5) – LOSS

Sunday Night Football:

  • Bears at 49ers (-2.5)
    • The pick: 49ers (-2.5) – BEST BET – WIN

Monday Night Football:

  • Rams (-7.5) at Falcons
    • The pick:Rams (-7.5) – LOSS

Previous Week’s Record: 11-5

Regular Season Record: 120-120-0 (50.00%)

Postseason Record: N/A

Best Bet Record: 12-4

Last Season’s Record: 139-133-0 (51.10%)

Click here for my Full Historical Pick Records


King of the Hill aka Lock of the Week aka Survivor Pool Picks:
In this section, I will post my pick for a survivor pool. Once a team is used, I can’t use them again for the rest of the season. The team selected only has to win the game, not cover the spread. Pick One and Pick Two are independent of each other. If I use a team with Pick One, I can use them later with Pick Two.

Week Pick One Pick Two
Week 1 Cardinals – Win Broncos – Win
Week 2 Cowboys – Win Cardinals – Win
Week 3 Seahawks – Win Bucs – Win
Week 4 Broncos – Win Texans – Win
Week 5 Lions – Win Colts – Win
Week 6 Packers – Win Rams – Win
Week 7 Patriots – Win Bears – Win
Week 8 Colts – Win Falcons – Loss
Week 9 Rams – Win Packers – Loss
Week 10 Bills – Loss Panthers – Loss
Week 11 49ers – Win Patriots – Win
Week 12 Ravens – Win Seahawks – Win
Week 13 Chargers – Win Jaguars – Win
Week 14 Bucs – Loss Browns – Loss
Week 15 Jagaurs – Win 49ers – Win
Week 16 Texans – Win Bills – Win
Week 17 Bengals – Win Giants – Win
Week 18
Total 15-2 13-4
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