2025-26 NFL Picks Against the Spread: Week 3

The MikesPickz NFL Picks are back again for the 2025-26 season.

As usual, I will make my picks for each game, every week of the NFL season using the point spread from the ESPN Pigskin Pick’em Challenge. After each week, the post will be updated with the results. My full pick record for all seasons (19 and counting) can be found on the historical picks page.

The favorite will be marked with the spread in parenthesis next to the team name. For example, Patriots (-6.5). My best bet is the team that I feel is most likely to win and cover the spread this week.

Welcome to Week 3 of the NFL Season! Without further adieu, here are my picks:

Week 3 BYE WEEKS: None
Best Bet: 49ers (-1.5)
Week 3 Recap: 0-1-0, 0-0 Best Bet, 0-0 Survivor pool

Thursday Night Football:

  • Dolphins at Bills (-12.5)
    • The pick: Bills (-12.5) – LOSS

Sunday Early Games:

  • Packers (-7.5) at Browns
    • The pick: Packers (-7.5)
  • Colts (-3.5) at Titans
    • The pick: Colts (-3.5)
  • Bengals at Vikings (-2.5)
    • The pick: Vikings (-2.5)
  • Steelers at Patriots (-1.5)
    • The pick: Patriots (-1.5)
  • Rams at Eagles (-3.5)
    • The pick: Rams (+3.5)
  • Jets at Bucs (-6.5)
    • The pick: Bucs (-6.5)
  • Raiders at Commanders (-2.5)
    • The pick: Raiders (+2.5)
  • Falcons (-5.5) at Panthers
    • The pick: Panthers (+5.5)
  • Texans at Jaguars (-1.5)
    • The pick: Texans (+1.5)

Sunday Late Games:

  • Broncos at Chargers (-2.5)
    • The pick: Chargers (-2.5)
  • Saints at Seahawks (-7.5)
    • The pick: Seahawks (-7.5)
  • Cowboys at Bears (-1.5)
    • The pick: Cowboys (+1.5)
  • Cardinals at 49ers (-1.5)
    • The pick: 49ers (-1.5) – BEST BET

Sunday Night Football:

  • Chiefs (-5.5) at Giants
    • The pick: Chiefs (-5.5)

Monday Night Football:

  • Lions at Ravens (-5.5)
    • The pick: Lions (+5.5)

Previous Week’s Record: 9-7-0

Regular Season Record: 17-15-0 (53.13%)

Postseason Record: N/A

Best Bet Record: 1-1

Last Season’s Record: 139-133-0 (51.10%)

Click here for my Full Historical Pick Records


King of the Hill aka Lock of the Week aka Survivor Pool Picks:
In this section, I will post my pick for a survivor pool. Once a team is used, I can’t use them again for the rest of the season. The team selected only has to win the game, not cover the spread. Pick One and Pick Two are independent of each other. If I use a team with Pick One, I can use them later with Pick Two.

Week Pick One Pick Two
Week 1 Cardinals – Win Broncos – Win
Week 2 Cowboys – Win Cardinals – Win
Week 3 Seahawks Bucs
Week 4
Week 5
Week 6
Week 7
Week 8
Week 9
Week 10
Week 11
Week 12
Week 13
Week 14
Week 15
Week 16
Week 17
Week 18
Total 2-0 2-0
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