The MikesPickz NFL Picks are back again for the 2025-26 season.
As usual, I will make my picks for each game, every week of the NFL season using the point spread from the ESPN Pigskin Pick’em Challenge. After each week, the post will be updated with the results. My full pick record for all seasons (19 and counting) can be found on the historical picks page.
The favorite will be marked with the spread in parenthesis next to the team name. For example, Patriots (-6.5). My best bet is the team that I feel is most likely to win and cover the spread this week.
Welcome to Wild Card Weekend of the 2025-26 NFL Season! Without further adieu, here are my picks:
Wild Card Weekend BYE WEEKS: Broncos, Seahawks
Best Bet: Patriots (-3.5) – WIN
Wild Card Recap: 5-1, 1-0 Best Bet
Saturday Football:
- Rams (-10.5) at Panthers
- The pick: Panthers (+10.5) – WIN
- Packers at Bears (-1.5)
- The pick: Bears (-1.5) – WIN
Sunday Football:
- Bills (-1.5) at Jaguars
- The pick: Jaguars (+1.5) – LOSS
- 49ers at Eagles (-4.5)
- The pick: 49ers (+4.5) – WIN
- Chargers at Patriots (-3.5)
- The pick: Patriots (-3.5) – BEST BET – WIN
Monday Night Football:
- Texans (-3.5) at Steelers
- The pick: Texans (-3.5) – WIN
Regular Season Record: 134-138-0 (49.26%)
Postseason Record: N/A
Best Bet Record: 13-5
Last Season’s Record: 139-133-0 (51.10%)
Click here for my Full Historical Pick Records
King of the Hill aka Lock of the Week aka Survivor Pool Picks:
In this section, I will post my pick for a survivor pool. Once a team is used, I can’t use them again for the rest of the season. The team selected only has to win the game, not cover the spread. Pick One and Pick Two are independent of each other. If I use a team with Pick One, I can use them later with Pick Two.
| Week | Pick One | Pick Two |
| Week 1 | Cardinals – Win | Broncos – Win |
| Week 2 | Cowboys – Win | Cardinals – Win |
| Week 3 | Seahawks – Win | Bucs – Win |
| Week 4 | Broncos – Win | Texans – Win |
| Week 5 | Lions – Win | Colts – Win |
| Week 6 | Packers – Win | Rams – Win |
| Week 7 | Patriots – Win | Bears – Win |
| Week 8 | Colts – Win | Falcons – Loss |
| Week 9 | Rams – Win | Packers – Loss |
| Week 10 | Bills – Loss | Panthers – Loss |
| Week 11 | 49ers – Win | Patriots – Win |
| Week 12 | Ravens – Win | Seahawks – Win |
| Week 13 | Chargers – Win | Jaguars – Win |
| Week 14 | Bucs – Loss | Browns – Loss |
| Week 15 | Jaguars – Win | 49ers – Win |
| Week 16 | Texans – Win | Bills – Win |
| Week 17 | Bengals – Win | Giants – Win |
| Week 18 | Vikings – Win | Bengals – Loss |
| Total | 16-2 | 13-5 |
